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KMID : 0382619900100010443
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Hanyang Journal of Medicine
1990 Volume.10 No. 1 p.443 ~ p.449
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Spinal Bone Mineral Density in Normal Women and Patients with Cervical Cancer
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Abstract
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It has been suggested that the hypercalcemia found in the patients of squamous cell carcinoma is caused by increased osteoclastic bone resorption and decreased bone formation. It is expected that the bone mineral density(BMD) is altered in these patients. But there has been no report concerning measurement of the BMD in the patients with cervical cancer.
Using dual photon absorptiometry, spinal BMD was measured in 82 normal women(ages 30-86yr) and 61(ages 32-83yr) cervical cancer patients. In normal women BMD correlated well with age(r= -0.708, P=0.001), and was peakin age 30 to 39 (1.26±0.09g/cm²). The annual decrease of BMD from age 40-69 averaged almost 0.014g/cm²(Y=1.855-0.014 X age). But BMD was not correlated with weight (r=0.236, P=0.08) and height (r=0.238, P=0.08). The mean values of BMD of the patients with cervical cancer were similar with those of normal women before age 50 and after 60 years of age, but was significantly reduced (P=0.001) in age 50-59 than that of normal women. There was no difference in the mean values of BMD according to stage of disease. The levels of serum calcium in the patients were within normal limits. From the above results it is suggested that the cervical cancer patients in age 50-59 are high risk group for the development of osteoporosis.
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